![]() ![]() Once fentanyl is absorbed into the skin, it forms a depot of drug in the upper layers of the skin. The Duragesic patch consists of four layers: (1) a backing layer of polyester film (2) a drug reservoir of fentanyl and an alcohol gel with hydroxyethyl cellulose (to enhance the drug delivery rate) (3) an ethylene-vinyl acetate copylymer membrane that controls the rate of fentanyl delivery to the skin surface and (4) a fentanyl containing silicone adhesive material. Duragesic is a transdermal system-the medicine, fentanyl, is absorbed through the patient’s skin and into the bloodstream, providing pain relief for up to three days (72 hours) from a single patch application. Duragesic® is the trade name for a pain-medication patch containing fentanyl, a potent opioid analgesic.
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